Dutch Ref

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Dutchreferee
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Re: Dutch Ref

Post by Dutchreferee » 30 Mar 2020, 17:57

What do you think about the plan playing the last 92 Premier League in june & juli ? What if one of the players got infected with covid 19 ?

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Dutchreferee
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Re: Dutch Ref

Post by Dutchreferee » 30 Mar 2020, 17:58

Dutchreferee wrote:
30 Mar 2020, 17:57
What do you think about the plan playing the last 92 Premier League in june & juli ? What if one of the players got infected with covid 19 ?
We will hear tomorrow what will happen overhere in Holland.

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andy
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Re: Dutch Ref

Post by andy » 30 Mar 2020, 19:59

Dutchreferee wrote:
30 Mar 2020, 17:57
What do you think about the plan playing the last 92 Premier League in june & juli ? What if one of the players got infected with covid 19 ?
If possible, why not?
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Dutchreferee
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Re: Dutch Ref

Post by Dutchreferee » 31 Mar 2020, 09:08

andy wrote:
30 Mar 2020, 19:59
Dutchreferee wrote:
30 Mar 2020, 17:57
What do you think about the plan playing the last 92 Premier League in june & juli ? What if one of the players got infected with covid 19 ?
If possible, why not?
I mean , when one the players or staff got infected during this period, they have to go in quarantaine for 14 days and can't play anymore during this last matches. What about the opponent ? Do they have to go in quarantaine to ?

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andy
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Re: Dutch Ref

Post by andy » 31 Mar 2020, 15:48

Dutchreferee wrote:
31 Mar 2020, 09:08
andy wrote:
30 Mar 2020, 19:59
Dutchreferee wrote:
30 Mar 2020, 17:57
What do you think about the plan playing the last 92 Premier League in june & juli ? What if one of the players got infected with covid 19 ?
If possible, why not?
I mean , when one the players or staff got infected during this period, they have to go in quarantaine for 14 days and can't play anymore during this last matches. What about the opponent ? Do they have to go in quarantaine to ?
Oh I see. I guess though Ronnie that could happen whenever football starts again because I can't see this virus being TOTALLY eliminated for a very long time. Even when restrictions are lifted the virus is still going to be there until a vaccination is available. Could be more than a year away.
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andy
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Re: Dutch Ref

Post by andy » 31 Mar 2020, 15:51

I also wonder how many players have returned to their home countries since football shut down, and how many may bring it back from countries that will still be suffering even if Europe is much improved. There is a lot of water to go under the bridge yet no matter what the outcome.
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Re: Dutch Ref

Post by Noggin » 31 Mar 2020, 16:12

andy wrote:[ Even when restrictions are lifted the virus is still going to be there until a vaccination is available. Could be more than a year away.
Normally the sequence of trials/studies are nonclinical (animal), Phase 1 (first in man, healthy volunteers), Phase 2 (people suffering with the condition), Phase 3 (comparative with placebo, large scale).

Covid-19 trials are taking place around the world with the nonclinical studies in parallel with the P1 studies, but there is little chance in my opinion that a regulatory agency (MHRA for UK, FDA for US, MD for Netherlands) will allow P2 studies to commence before the nonclinical work has concluded because of the consequences if things went wrong.

Amazingly, one of the factors that limits the speed of nonclincal studies is how fast rabbits breed! This is because all medicines licenced in the UK (and many other countries) have to do teratology ie multi-generational studies in the same species.

Of course that assumes that the covid-19 virus does not change its RNA, because that would mean that any candidate vaccine needs to be changed too which is why the 'flu vaccine has different chemistry every year

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Re: Dutch Ref

Post by andy » 31 Mar 2020, 16:20

I was just about to say that. ;D
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Re: Dutch Ref

Post by Noggin » 31 Mar 2020, 17:08

andy wrote:
31 Mar 2020, 16:20
I was just about to say that. ;D
Shall I sent you the invoice for consultancy fees immediately, or would you like it accrued to your account?

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Re: Dutch Ref

Post by Noggin » 31 Mar 2020, 17:16

The serious point is that the regulatory agencies will support extraordinary measures such as trials being done in parallel and will expedite regulatory submissions to approve drugs for human use, but it is extremely unlikely that they will be willing to compromise safety.

They are also issuing guidance to industry so that that the usual rules are relaxed for other developmental drugs so that these are not compromised by current circumstances. Been dealing with one such deviation today :-)

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